Izabelle Evans Apeal - Recently Updated Pages

News & Updates on Izabelle

holliemchugh — Wed, 26 Aug 2009 09:37:30 CDT

Here you can keep up to date with little izabelle and how she is getting on!

Izabelle's Birth story part 1:

Izabelle's Story part 2:

Fundraising Central

holliemchugh — Thu, 30 Jul 2009 05:52:34 CDT

Please help Izabelle by giving a donation by clicking on the link below, every little helps!

Or you can send a cheque payable to Izabelle Evans,
2 magdala court,
4 magdala road,
Hayling Island,
PO11 0BH

https://www.paypal.com/cgi-bin/webscr?cmd=_donations&business=holliemchugh%40hotmail%2ecom&item_name=Izabelle&no_shipping=0&no_note=1&tax=0&currency_code=GBP&lc=GB&bn=PP%2dDonationsBF&charset=UTF%2d8

Below is how much to date has been raised since the 10th of march 2008. I just want to say a great big thankyou to everyone who has helped, it means so much to us!

Raised so far since 10.03.2008

£34,161.02p

From	Date	Amount
Jamielee Davey	11.03.2008	£50
Kayleigh Brock	18.03.2008	£20
Sian Smith	01.04.2008	£20
Nicola Hall	07.05.2008	£5
Julie Metcalfe	08.07.2008	£10
Charmed Life Music, LLC	03.08.2008	£50
Zabrina McHugh	09.08.2008	£50
John Payce	30.08.2008	£15
Anonymous	30.08.2008	£250
Carl Haworth	30.08.2008	£20
David Horne	30.08.2008	£500
David Horne	30.08.2008	£500
Mark Taylor	30.08.2008	£100
Kevin Bond	01.09.2008	£10
Hollie Mchugh	01.09.2008	£40
Lisa Lymer	04.09.2008	£50
Michael Rees	06.09.2008	£200
Anonymous	08.09.2008	£100
John Moore	08.09.2008	£10
Barry Watson	09.09.2008	£50
	09.09.2008	£15
	09.09.2008	£10
Anonymous	13.09.2008	£500
Colin Reed	14.09.2008	£50
Anonymous	14.09.2008	£50
Stuart and Ann Waring	14.09.2008	£1,000
Sandra	23.09.2008	£5
E.L.Roberts	26.09.2008	£50
Rose	06.10.2008	£40
Anonymous	10.10.2008	£30
Mr R S O'Shea	15.10.2008	£100
Mr M J Harris & Mrs P Harris	16.10.2008	£50
Portsmouth Motorbike Lads	19.10.2008	£58
Andy, Kath, Jodie & Franky (Kent)	19.10.2008	£50
Matt Lennox 3M .Health Care	19.10.2008	£150
Kevin, Rotherham Yorkshire	19.10.2008	£50
MA & PA Fishtank & Friends	19.10.2008	£381
M.Byrne, All the Ladies who helped raise Money.	20.10.2008	£51.63
The Hayling Island Naval Association	20.10.2008	£100
Ping Pang	23.10.2008	£10
Den Hookings and Family, and their late mum Maria.	01.11.2008	£200
Shotgun smile gig, raffle and 10p from every pint sold at The Milton Arms pub in portsmouth	03.11.2008	£607.33
Clare Cassidy	03.11.2008	£20
Mr RJ Dowding & Mrs P Dowding	13.11.2008	£20
Vanessa & Lindsay Gowers, Money raised from the Masonic Ladies Night, Utilitas Lodge, Great Queen Street.	19.11.2008	£1000
The Langstone Harbour Fishermens Association	21.11.2008	£250
Steve Montague	21.11.2008	£200
Janet & Christine	26.11.2008	£50
Mr C E F Hallett	27.11.2008	£100
R P King	01.12.2008	£10
Den Hookings and Family on behalf of there late mum Maria.	01.12.2008	£20
Mengham Infant School	04.12.2008	£53.20
S J Richardson	04.12.2008	£20
R G Clapperton	04.12.2008	£40
Foresters Friendly Society	04.12.2008	£100
Liz	04.12.2008	£30
Co-op - Buckets on tills	12.12.2008	£555.54
Bob Hey - who ate 6 raw eggs, with the shells on!	12.12.2008	£1793.49
Scott Cobb- Who raised money by doing the great south run	12.12.2008	£439.60
Charity bottle & charity punch	12.12.2008	£264.27
Golf society	12.12.2008	£150
Halloween NIght - (fine bucket for not being in fancy dress)	12.12.2008	£186.82
Johnny Madden - washing machine raffle	12.12.2008	£330.00
Auction of pictures and football donated by pompey football club. (Tony Male)	12.12.2008	£115
Funds raised at the Masonic Christmas party-Raffle, Drayton lodge	14.12.2008	£500
Anonymous	15.12.2008	£30
Moggys Cafe & Chippy	17.12.2008	£190
Andrew Tosh, Hairdresser	17.12.2008	£40
Ma & Pa Fishtank & Friends	17.12.2008	£176
Lilly May Smith (aged 5)	17.12.2008	£4
Hayling Hardware	21.12.2008	£1250
Mrs D V Saunders	21.12.2008	£30
Mr D O'Neill & Mrs P O'Neill	03.12.2009	£10
Eric Armitage	03.12.2009	£20
Neil Ward	03.12.2009	£50
Crofton School	18.12.2008	£500
Alan McKay	10.01.2009	£10
Phillip Leek	10.01.2009	£10
Jessica Hancock	10.01.2009	£10
Lee Baker	10.01.2009	£50
Hayling Island Businessmens Club	10.01.2009	£400
Anonymous	10.01.2009	£1765
Raffle of signed Pompey shirt & Shotgunsmile CD sales	10.01.2009	£209
Izabelle's Night (entry and raffle)	10.01.2009	£110.15p
Mr S Nicholson & Mrs M Nicholson	10.01.2009	£50
G R Dridge	10.01.2009	£50
Mrs S S Miller	20.01.2009	£10
M M Pennery	20.01.2009	£20
N E Barrett	20.01.2009	£20
Finesse, Hairdressers, Hayling Island.	20.01.2009	£210
Hayling Island Community Center	20.01.2009	£50
Alan Tingle	20.01.2009	£100
Martin Price	20.01.2009	£10
Anonymous	20.01.2009	£500
Reflections (group of lady Barbershop Singers)	24.01.2009	£350
Sponserd Fancy Dress Walk. (Havant to Portsmouth)	27.01.2009	£1417.19
Mrs B Davis	28.01.2009	£10
Hayling United Football Club	29.01.2009	£400
Mr A N J McKay	11.02.2009	£100
Money raised from party weekend at south downs. (southdowns holiday village)	11.02.2009	£200
More donations for the Fancy dress walk	11.02.2009	£137
Rotary Club of Havant	12.02.2009	£250
Jan Pope	12.02.2009	£20
Raised by Local Pigeon Fanciers on there annual coach trip to blackpool for " The Show Of The Year"	25.02.2009	£110
Jeannette Jordan, Hayling Island	26.02.2009	£485
The Eagle Riders	07.03.2009	£510
Money Raised from the quiz night at The Maypole Inn (Hayling Island)	19.03.2009	£553.50
Hayling Community Pre-School (who donated half of there Christmas present money)	19.03.2009	£60
Mr D.G Cush	19.03.2009	£20
Mr C.W Tilley & Mrs J Tilley	20.03.2009	£25
Mrs J.E Comlay	20.03.2009	£20
Mr RJ Dowding & Mrs P Dowding	20.03.2009	£20
Mavis & John Davidson	20.03.2009	£10
Patrick McDonagh, Sheila McDonagh & Family	20.03.2009	£50
Mr A R Bryant & Mrs A M Bryant	20.03.2009	£20
Mr & Mrs Brewer	21.03.2009	£20
P.M.G Fricker	21.03.2009	£50
G.R.P Harmer	21.03.2009	£50
LT.CMDR D A Bartlett & Mrs D.E Bartlett	21.03.2009	£20
Mrs E.M Palmer	21.03.2009	£20
Mrs. M.M Bern	21.03.2009	£10
Mr A.W Scott	21.03.2009	£15
Mrs.D.A.Cousins	21.03.2009	£15
Mr E.S Grist	21.03.2009	£20
Paul & Margaret Faulkner	22.03.2009	£200
Eric Armitage	22.03.2009	£10
Hayling Island Baptist Church	23.03.2009	£85
Cards 4 Occasions	23.03.2009	£5
Mrs L.M Robertshaw	24.03.2009	£50
Mrs M.V Avery	24.03.2009	£20
M E Shelley	24.03.2009	£500
A J Collinson	25.03.2009	£17
Miss Sonia Norman	25.03.2009	£50
Mrs June R Colston	26.03.2009	£20
Mr D.O Dyer & Mrs V.G Dyer	26.03.2009	£5
I.P Munro	26.03.2009	£5
C Barnes	27.03.2006	£30
Mrs June M Rigg	27.03.2006	£10
Kim : The Betting Shop (Stamshaw)	01.04.2009	£22.25
Andrew Price Hairdresser's	01.04.2009	£3.55
Kieran: MCutting	01.04.2009	£8.65
Andrew Tosh Hairdresser's	01.04.2009	£39.55
Moggies Cafe/Chippy	01.04.2009	£93
Leah Bartholomew	01.04.2009	£50.04
Ma & Pa Fishtank & Friends	01.04.2009	£183
Money Raised at Sainsbury's Store Portsmouth	03.04.2009	£500
Mr Ken G Hunt & Mrs Pam J Hunt	03.04.2009	£10
Christophe Bull	03.04.2009	£10
R E J & Mrs A Curtis (Anne & Roy)	12.04.2009	£50
Mr E Wilson	20.04.2009	£25
Hayling Island Masonic Lodge	21.04.2009	£500
Money raised from fundrasing night at the lifeboat, on Hayling Island	09.05.2009	£608.69
Money donated from Shotgun smile from the fundrasing night on 9.5.2009	09.05.2009	£117
Money rasied at the quiz night, by Hayling Island Baptist Church.	12.05.2009	£80
Mrs GM Horn	16.05.2009	£5
Anonymous	16.05.2009	£5
Kitten	16.05.2009	£5
Mr H J Leach	19.05.2009	£5
Mrs E M Barnes	19.05.2009	£25
Money raised by the Hayling Island FireFighters	20.05.2009	£283.30
Mr E S Grist	21.05.2009	£20
A R & E M Bedford	22.05.2009	£50
Sheila Burton	23.05.2009	£50
Hampshire Association for the care of the blind.	28.05.2009	£100
Links Lodge Charity	01.06.2009	£250
Money raised by all the members of the Forest Lodge No 6612 and their families.	15.06.2009	£1500
Mr DG White & Mrs CE White	20.06.2009	£132
The Alwarestock Freemason's Lodge No. 7805 in Gosport.	20.06.2009	£100
Money Raised by Lindsey Gowers, by completeing a sponserd bike ride from Ventnor, Isle of Wight, through to St Malo, France.	21.06.2009	£600
Money raised by Matthew Lane age 11. who completed a 2 mile jog!!!	22.06.2009	£103
Tudor Rose Lodge No. 9477 EC	25.06.2009	£250
Bands In The Barn	25.06.2009	£3000
Money raised by all staff and custumers at The White Hart pub.	28.06.2009	£728
Money Rasied by The summer Guitar workshop.	11.07.2009	£414.25
The Hayling Island and Gorron Twinning Association	12.07.2009	£500

Raised so far £34,161.02p

THANKYOU EVERYONE!!

See also: Calendar | News & Updates | Meeting Agendas & Notes

Izabelle Needs your help!!

holliemchugh — Fri, 26 Jun 2009 05:30:44 CDT

Welcome to Izabelle's sight!!

We have now reached our target!!!! THANKYOU everybody so much who has helped us out in someway!
xxxxxxx

This site is dedicated to Izabelle Louise Lyndsey Evans. Izabelle needs your help, She needs stem cell treatment to give her a chance to see for the very 1st time, and to help her live a better life. Izabelle was born with a very very rare medical condition, that effects 5 in 1 million babies. She was born with Septo Optic Dysplasia, Diabetes Insipidus and is also blind. Please follow the links to find out more information about Izabelle and about how you could make the world of difference to this little girl.

About Izabelle (Izabelle, Her Medical conditions,The Treatment)	Events Calender
News & Updates on Izabelle (Including video's)	Fundraising Central (please help)
Photo Gallery! (Recent Photo's added)	Contact Me

Succsess Story's

Im in The News!

Need more? Add graphics and flourishes that match your wiki design (they're free from Paint Splatters)

About Izabelle

holliemchugh — Tue, 23 Jun 2009 13:04:16 CDT

About Izabelle:
Izabelle is 15months old. She was born on december 3rd 2006 with a very rare brain condition called Septo Optic Dysplaisa effecting 5 in 1 million babies.This causes mulitipule problems for her, including pituitary deficiencies, hormone deficiencies, low muscle tone, seizures, and blindess. Izabelle also has Diabetes Insipidus (which is completey different to the normal Diabetes), Hypothyroidism, Adrenal Insufficiency, Growth Hormone Deficiency (this affects bone density, fat storage, cholesterol storage, mental health etc) Izabelle has spent a lot of her life in hospital, She has to have medicine everyday for the rest of life, if she gets sick and can not have her medicine she could die, soon she will also need an injection everyday so that her bones can develop properley and she can grow. Izabelle is a very happy little girl and it would mean the world to her and her parents if she could have the chance to see all the beatuifull things the world has to offer, and could also be able to live a better life! Stem Cell treatment is not avalible in her current country the UK, so she would need to travel to China for the treatment to be carried out.

Information about Izabelles medical condition:
Septo-optic dysplasia (SOD) is a rare disorder characterized by abnormal development of the optic disk, pituitary deficiencies, and often agenesis (absence) of the septum pellucidum (the part of the brain that separates the anterior horns or the lateral ventricles of the brain). Symptoms may include blindness in one or both eyes, pupil dilation in response to light, nystagmus (a rapid, involuntary to-and-fro movement of the eyes), inward and outward deviation of the eyes, hypotonia (low muscle tone), and hormonal problems. Seizures may also occur. In a few cases, jaundice (prolonged yellow skin discoloration) may occur at birth. Intellectual problems vary in severity among individuals. While some children with SOD have normal intelligence, others have learning disabilities and mental retardation. Most, however, are developmentally delayed due to vision impairment or neurological problems.

A note from her parents:
This little girl is our life, even with all her many medical problems that she has and the challenges she face's each day she is always happy and has a big smile on her face. we are hoping to raise enough money for Izabelle to have Stem cell treatment to give her a chance to see the world around her and let her live a better life when she's older. This treatment is very expensive and without your help we cant help her.

Please help Izabelle by making a small donation, by clicking on the link below, or by sending a cheque payable to Izabelle Evans, at:
2 magdala court,
4 magdala road,
Hayling Island,
hampshire
PO11 OBH

https://www.paypal.com/cgi-bin/webscr?cmd=_donations&business=holliemchugh%40hotmail%2ecom&item_name=Izabelle&no_shipping=0&no_note=1&tax=0&currency_code=GBP&lc=GB&bn=PP%2dDonationsBF&charset=UTF%2d8

Events Calendar

holliemchugh — Tue, 23 Jun 2009 13:01:24 CDT

Here is Izabelle's events calender. You will be able to check here for any upcoming events that have been planned to help raise money.Just click threw the calender to check for events that will be held at later dates. If you have any ideas for events or feel you would like to help in such a way please feel free to contact me. My information is in the Contact me section of the website.

Upcoming Events:

Date: --- Saturday 9th May Name of Event: --- Shotgunsmile gig at lifeboat pub Location: --- Lifeboat pub, Hayling Island Contact Person: --- Hollie McHugh, James Evans 02392 348662	Date: --- Saturday June 13th Name of Event: --- Bands in the Barn Location: --- Manor Farm, Hayling island Contact Person: --- http://www.bandsinthebarn.com/
Date: --- Thursday, March 12th Name of Event: --- Pub Quiz Location: --- The Maypole, Hayling Island Contact Person: ---	Date: --- July 9th 2009 Name of Event: --- Derek Hasted's, Guitar Workshop present Summer Concert! Location: ---St Nicolas Church Center, Bedhampton. Contact Person: --- See Calender above for more info.

Past Events:

Date: --- saturday 30th august Name of Event: --- fundrasing Location: --- The Blue Anchor Contact Person: ---Karen Coombes	Date: --- Sunday 23rd Novmeber 2008 Name of Event: --- fancy dress sponserd walk Location: --- Havant to Portsmouth Contact Person: --- Laura Tondeur, Hollie Mchugh
Date: ---Saturday 11th October Name of Event: --- Shotgun Smile Gig Location: --- The Milton Arms pub, Portsmouth Contact Person: --- Jon Wheeler	Date: --- Saturday 10th January 2009 Name of Event: --- Izabelle's Night Location: --- Hayling Island, Comunity Center Contact Person: --- Hollie Mchugh or James Evans 02392 348662
Date:

Event Photo's

holliemchugh — Sun, 08 Mar 2009 13:23:13 CDT

Here are a selection of Photos from Events that have helped raise money for Izabelle's eye treatment.

The Fancy dress walk.

A 14 mile walk, most of it was done in the rain until finally the sun came out!

Izabelle's Night

A night of fun to raise money for Izabelle, including live music from bands, Shotgun Smile, Rusty String's and Empire Creek, Also a raffle where local business donated the prizes!!

(James on the door)

A Big THANKYOU!

holliemchugh — Sun, 08 Mar 2009 12:30:18 CDT

Showcase of the companies that support your organization below!

	Thankyou to Renee Lopez for making a special page on your website about Izabelle. www.charmedlifemusic.com/izabellestory.cfm
	Thankyou to Kathleen O'Neill and Jeff Travis from The News, to help spread awareness of Izabelle and her fund raising, and a big thankyou to Elise brewerton who is keeping updates of Izabelle in the news.
	Thankyou to The Blue Anchor, In London Road Porstmouth, for arranging and holding a fundrasing weekend for Izabelle.
	A HUGH Thankyou to The Hayling Island Businessmens' club, who are covering the costs of the flights to china and back for Izabelle, James and myself. This is going to help us out a great deal and we very much appreciate it. THANKYOU!!!
SHOTGUN SMILE	Thankyou to the band ShotGun smile, who saw Izabelle's story in the paper and arranged a charity gig for her at the Milton arms pub in Portsmouth. Thank you .
The Milton Arms Pub, Portsmouth	Thank you to the Milton Arms pub in Portsmouth, who allowed shotgun smile to hold there Charity gig at your pub and for donating a percentage of all the beers sold to Izabelle, also for arranging a raffle for Izabelle out of your own funds. Thank you so much we appreciate everything you have done for a little Izabelle.
The co op, Hayling Island	Thankyou to the Co-Op on Hayling Island, who have placed buckets on the end of there tills for 2 weeks to help Izabelle reach her target, and a special thankyou to Lana Kelsey Owen who's idea it was and who made it possible and we cant forget all the shoppers who put money into the buckets and raised a total amount of £555.54!!!!
Hairdressers Finesse, Hayling Island	Thankyou to Finesse who have arranged a murder mystry competetion, where you can win a Free cut and styling at the salon including a deep conditioning treatment.
Laura Tondeur and Andi Prowting	A BIG Thankyou to Laura and Andi who have arranged a 10.3mile sponserd walk, to help raise money for Izzy. Hopefully the weather will stay dry for us.
The masonic ladies Night, Utilities Lodge, Great Queen Street which was held on 1st of November 2008 at The Langstone Hotel.	Thankyou you to Vanessa and Linsay Gowers and to all who attended the ladies night and helped raise money for Izabelle. thankyou for thinking of Izabelle and donating your money to her eye treatment, we cant thank you enough!
Fancy dress walk,	Thankyou to everyone who turned up in the pouring rain and walked in fancy dress for 14 miles from havant to gunwharf!!!
Mengham Infant School	We would like to thank all the staff and pupils from mengham Infant School for raising the £53.20p from your non-uniform day. We hope you all had a lot of fun dressing up in your Halloween outfits!!! Thank you all so much. x
The Foresters Friendly Society.	Thank you to everyone at the Foresters Friendly Society who held a fish and chip supper and helped raise £100, and thank you for the beautiful bear you gave to Izabelle xxx
Bob Hey	Thank you for being so brave for munching down 6 raw eggs with the shells still ON!!!! You manged to raise £1793.49!!! Well done, you raised alot of money for Izzy and we cant thank you enough!
Scott Cobb	A Great big thank you to Scott Cobb, who Ran the Great South Run and Raised £439.60!!! We are very grateful!! and well done to you!!!
Johnny Madden	A hugh thank you to Johnny Madden who donated a washing machine which was raffled at £1 a ticket rasing a total amount of £330!!! THANK YOU!
Hayling Hardware	We want to Thank Hayling Hardware, for taking it upon themselves to organise a raffle in there store. Selling tickets at £1 each they raised a whopping £1250.00 for Izabelle. Thank you so so much x
	We want to Thank Somerfield For donating a store gift voucher, that was won in a raffle at Izabelle's Fundrasing Evening.
	Thank you to ocean FM who donated a signed photo of Will Young for Izabelle's raffle, and also advertised her fundrasing evening on there website.
	Thank you to Madeleins Beauty Salon on Hayling Island who donated a Back, Neck & Shoulder massage to one of the winners from Izabelle's raffle.
	Thank you Very much to the salon Hair, on Hayling Island who very kindly donated 3 different sets of prizes for Izabelle's raffle. Paul Mitchell Shampoo and Conditioner A set of lovely smelling candles in a presentation box along with a store voucher. GHD shampoo and hair wax. All of which where presented in black tie bags.
	We would like to Thank Cards 4 Occasions, who kindly donated a large soft cuddly teddy which was presented in a large silver gift box.
	Thank you to The Hayling Island Community Center who donated a bottle of wine towards Izabelle's raffle and sent a cheque to Izabelle's Funds.
	Thank you to The Ferry Boat on Hayling Island, who donated a lovely bottle of wine to Izabelle's raffle.
	We would like to thank The Squidgey Bug store on Hayling Island, who donated a store gift voucher to one of the winners of Izabelle's raffle.
	Thank you to H.I.A.D.S who donated a voucher for 2 people to see any H.I.A.D.S play at the Hayling Island Theater.
	Thank you very much to The Newtown Hotel who donated meal voucher for 2, up to the value of £50 to the one of the winners of Izabelle's raffle.
	We would like to thank Hayling Island Florist's who donated a beautifully presented plant to the raffle.
	Thank you to The Barley Moe who donated a meal for 2, to Izabelle's Raffle.
	WE would like to Thank Mrs Mary Boultwood who donated a lovely hamper to the raffle.
	Thank you to the band, Rusty strings, from Hayling Island, who gave up there spare time and played at Izabelle's night.
	We would like to Thank Empire Creek, From Hayling Island, who also performed on stage at Izabelle's Night
	Thank you again to Shotgun smile who have now played a second gig in order to help raise money for little Izabelle.
	Thankyou to The Eagle Riders who donated £510 towards Izabelle's eye treatment. Thankyou so much x

Contact Details

holliemchugh — Wed, 21 Jan 2009 08:21:47 CST

If you would like to get in contact for any reason please feel free to email us.

James (Izabelle's Dad) - jamesevans125@hotmail.com / Hollie (Izabelle's Mum) - miz_hollie@hotmail.co.uk

Home Tel: 02392 348662

Thankyou for helping and supporting my daughter!

Im in The News!

holliemchugh — Tue, 06 Jan 2009 14:24:12 CST

Here Is the front page of The News on the 26th of August 2008:

Continued on page 3 below

The News, Wednesday, August 27th 2008:

Izabelle's news article from saturday 30th of August 2008:

Izabelle was also in The news as she won picture of the week! yay!!!

Hayling Islander, October 2008

Continued below..........

Wednesday, 5th November, 2008

Hayling Islander, December 2008

The News, Wednesday, October 8th, 2008.

The News, Wednesday, December 3rd, 2008.

Guestbook

holliemchugh — Wed, 12 Nov 2008 08:35:51 CST

This page is for members of Izabelles site where you can leave her messages of support or anything else you like or you can even use it as a chat room to discuss things with other members or myself.. Just become a member of her site in order to write here and then click on post a new thread. Thankyou.

Success Storys!

holliemchugh — Mon, 08 Sep 2008 09:16:50 CDT

Below are a number of links that will take you to other children's sites who have already received the treatment and some who are waiting to go.

Just click on the links below and see how Stem Cell Treatments have already helped others!!

Eleanor
http://www.eleanorshope.com/web/do/site/home;jsessionid=5816CFCCD40337DBBE799CCE30596772?ID=366720

Brandon
http://www.brandonsfightforsight.blogspot.com/

Cameron peterson
http://www.cameronsmiracleofsight.com/web/do/site/home?ID=248540

Rylee Bartlett
http://www.nomoredarkness.com/

Rylee Lovett
http://www.blessherwithsight.com/

Will Ford
http://helpwillsee.org/

Scarlett Birkmire
http://www.hopeforscarlett.com/web/do/site/home;jsessionid=2756442B1F821C1AA99FF52B7F3F8FF8?ID=377685

Jakob
http://www.jakobsfightforsight.com/

General Questions

holliemchugh — Mon, 08 Sep 2008 09:11:12 CDT

Questions and answers about stem cells:
(from the Hospital in China)

What is a Stem Cell (SC)? A stem cell is a cell that can renew itself and become other types of cells in the body. This ability to change into other types of tissue is known as “plasticity”.

What is a cord blood? Cord blood is collected for the baby’s Umbilical Cord after birth. Beike Bio-Tech has performed thousands of these types of collections. All cord blood is tested for infections and possible abnormalities prior to use.

Are stem cell transplants from cord blood safe? Yes, in fact doctors have been using these types of stem cells for over 40 years. The National institute of Health (NIH) has stated that they have seen no cases of cancer or other health issues in relation to this type of transplant.

How soon will I see results? Some patients have noticed improvement within 24 hours. Since this is too soon for the cells to have engrafted we believe these immediate results occur from the Neural Growth Factors used during the transplant process.

What should be done to prepare for a Stem Cell Transplant (SCT)? We advise that you undergo no drastic changes in medication I month prior to treatment, surgery should not be done at least one month prior to treatment and it is advised that you not receive immunizations at least one month prior to treatment.

What are the side effects of a SCT? The side effects are very minimal. Most common is a slight elevation in temperature lasting 12 to 24 hours. Some patients also experience mild to moderate headaches. Many recipients also experience some level of fatigue for a day or two.

What is the FDA’s position on Umbilical Cord Blood Stem Cells? The FDA has approved the use of these cells for over 80 conditions. Unfortunately approval for many illnesses and conditions has been slow to come which is why so many are opting to go outside the US for treatment.

Can you guarantee this treatment will work? No, there are simply no guarantees. People respond differently to treatment as there are so many variables to consider. There are however consistencies within all of our patients in regard to improvements.

Can I use my own cord blood or that of my own child’s? No: You can not transport blood products into the country. They have been frozen which lowers the viability of the cells. Our products are all processed fresh and never frozen. There is no quality control on a product from another lab.

How many patients (Chinese and foreigners) has Beike treated thus far? As of January 2008 we have treated approxiamatky 2500 patients.

In the years Beike has been working with umbilical cord stem cells has there been any cases of patients developing abnormal growths or tumors? No

Have any of Beike's patients suffered severe rejection? No

Have any of Beike's patients died as a result of treatment? No

Does Beike have plans to expand into the US and/or Canada? That process would take many years and several million dollars and this would not be cost effective as doing so would force the prices to be greatly increased.

Can you please explain what is the Nerve Growth factor and the importance of this in Stem Cell Therapy? Nerve growth factors in regards to those used in China are taken from the cord serum and encourage the growth and repair of neurons as well as enhancing the potential of the umbilical stem cells which are infused.

Can you please also explain the significance of the Cord Serum? It is full of many types of growth factors and a wide array of stem cells.

Is Beike doing research into other ways to regenerate white matter? Yes, we are currently conducting research and development of a product based with Amniotic Stem Cells that is looking promissing and hope to be able to offer this to clients in the latter part of 2008. We have also been refining the culture and processing techniques for bone marrow transplants using the patients own bone marrow and have installed a new bone marrow lab at out Hang Zhou facility. Currently we are doing bone marrow transplants only on adults and children with MD but hope to expand this as an option for other children over the age of 8 within a few months.

The Lengthy Version: Do cord blood cells need to be DNA matched and embryonic/fetal stem cells not? It is a misconception that embryonic and fetal cells do not have a fingerprint and can change into any type of cell while umbilical stem cells do have fingerprints and can not transform. It is incorrect to say that this leads to rejection issues with umbilical stem cells as it does not. As for references made to such things as "DNA" and/or "fingerprints" neither really applies to either type in their true and pure forms. It isn't DNA variations per se, but surface antigens, often referred to as "markers", that signal "self" from "other". "Self" being the bodies own matter and "other" being a foreign substance. The consensus of studies published in scientific literature is that human umbilical cord stem cells (hUCSCs) provoke little in the way of adverse reactions due to antigenic recognition by the recipient. Meaning that because they lack markers and the body sees them as "self". This is why anti-rejection medication is not needed when doing a SCT with hUCSCs in the manner that is done by Beike.

How do you make sure that the stem cells you are using are a match for the patient and will not be rejected? Umbilical Cord Stem Cells, aka UCSC’s, do not require matching. In the life span of a stem cell umbilical cord derived stem cells are considered to be the youngest or least mature of all the stem cell types. These UCSC's (Umbilical Cord Stem Cells) simply lack the exterior surface antigens (protein markers) which would indicate to the hosts body that the cell is “other” thus the recipients immune system sees it as “self”. Upon being transfused into the body the UCSC’s will of course be noted by the hosts immune system which will respond by releasing white blood cells, aka WBC’s, in effect sending these white blood cells out into the body to do a search for foreign substances. Upon encountering the stem cells the white blood cell (WBC) will literally bounce around the exterior of the stem cell checking it for very specific proteins which are attached to the cell’s exterior cell body. These proteins are considered a type of antigen marker. When the WBC can not locate the “foreign” antigen markers it reads the new stem cell as “self”. This allows the host’s body to receive the Umbilical Cord Stem Cells with no fear of rejection and thus no matching is required and “rejection” is not an issue.

What are stem cells? Stem cells are unspecialized cells that have two important characteristics that distinguish them from other cells in the body. First, they can replenish their numbers for long periods through cell division. Second, after receiving certain chemical signals, they can differentiate, or transform into specialized cells with specific functions, such as a heart cell or nerve cell.Stem cells can be classified by the extent to which they can differentiate into different cell types:

Totipotent stem cells can differentiate into any cell type in the body plus the placenta, which nourishes the embryo. A fertilized egg is a type of totipotent stem cell. Cells produced in the first few divisions of the fertilized egg are also totipotent.
Pluripotent stem cells are descendants of the totipotent stem cells of the embryo. These cells, which develop about four days after fertilization can differentiate into any cell type, except for totipotent stem cells and the cells of the placenta.
Multipotent stem cells are descendents of pluripotent stem cells and antecedents of specialized cells in particular tissues. For example, hematopoietic stem cells, which are found primarily in the bone marrow, give rise to all of the cells found in the blood, including red blood cells, white blood cells, and platelets. Another example is neural stem cells, which can differentiate into nerve cells and neural support cells called glia.
Progenitor cells (or unipotent stem cells) can produce only one cell type. For example, erythroid progenitor cells differentiate into only red blood cells. At the end of the long chain of cell divisions are t
erminally differentiated cells, such as a liver cell or lung cell, which are permanently committed to specific functions. These cells stay committed to their functions for the life of the organism or until a tumor develops. In the case of a tumor, the cells dedifferentiate, or return to a less mature state. The term adult stem cell refers to any cell which is found in a developed organism (such as an umbilical cord) that has two properties: the ability to divide and create another cell like itself and also divide and create a cell more differentiated than itself. Also known as somatic (from Greek Σωματικóς, "of the body") stem cells and germline (giving rise to gametes) stem cells, they can be found in children, as well as adults. Pluripotent adult stem cells are rare and generally small in number but can be found in a number of tissues including umbilical cord blood.[ Most adult stem cells are lineage-restricted, multipotent and are generally referred to by their tissue origin such as a Mesenchymal stem cell, adipose-derived stem cell, or endothelial stem cell etc.

What is cell therapy? Cell therapy can be defined as a group of new techniques, or technologies, that rely on replacing diseased or dysfunctional cells with healthy, functioning ones. These new techniques are being applied to a wide range of human diseases, including many types of cancer, neurological diseases such as Parkinson's and Lou Gehrig's Disease, spinal cord injuries, and Diabetes. Replacing dead cells in the retina with new ones may someday cure even presently incurable eye diseases such as glaucoma and macular degeneration. To understand how cell therapy works, it helps to understand the role of cells in the body.

Why are stem cells important from a medical perspective?

For decades, researchers have been studying the biology of stem cells to figure out how development works and to find new ways of treating health problems. Because stem cells can give rise to any tissue found in the body, they provide nearly limitless potential for medical applications. Current studies are researching how stem cells may be used to prevent or cure diseases and injuries such as Parkinson’s disease, type 1 diabetes, heart disease, spinal cord injury, Duchene’s muscular dystrophy, Alzheimer’s disease, strokes, burns, osteoarthritis, rheumatoid arthritis, vision, and hearing loss. Stem cells could also be used someday to replace or repair tissue damaged by disease or injury.

Since the stem cells are still an implant could not any implant be rejected? Technically we are not “implanting” the stem cells. We have two delivery methods; one is an “infusion” of the cells, growth factors and cord serum into the blood stream and the other is an “injection” of the cells and growth factors into the spinal canal where they then mix with the SCF (Cerebral Spinal Fluid). * We do not infuse or inject any Red Blood Cells. What creates rejection by the host body is the reaction between the host’s immune system and a foreign substance. When any foreign substance is placed into the body our immune systems are activated by a slight elevation in body temperature. Once activated the body alerts a very specific type of white blood cell (WBC). This type of cell will seek out the newly introduced stem cells. Its job is to determine weather the stem cell is a foreign substance. This determination process is commonly referred to as determining “self” from “other’. The WBC’s will literally bounce around the exterior surface of the stem cell. It is physically checking it for very specific protein markers known as “antigens”. These proteins located on the surface of the cell are like a secrete code and if the WBC does not see the right code it will determine the stem cell to be “self” and thus leave it alone to go about its business. Umbilical Cord Stem Cells lack the antigens that would identify them to the WBC as a foreign cell or as being “other”. The body’s immune system sees them as being “self” and no rejection occurs.

Is it true that umbilical cord derived stem cells have a genetic finger print and this leads to rejection issues? No, this is not true. References made to "DNA" and/or "fingerprints” does not apply to this type of stem cell. It isn't DNA variations per se, but surface antigens, often referred to as "markers", that signal "self" from "other". "Self" being the bodies own matter and "other" being a foreign substance. The consensus of studies published in scientific literature is that human umbilical cord stem cells (hUCSCs) provoke little in the way of adverse reactions due to antigenic recognition by the recipient. Meaning that they lack markers and the body sees them as "self". This is why anti-rejection medication is not needed when doing a SCT with hUCSCs.

Grafting vs. Host Disease (GVHD)

GVHD is one of the most common and life threatening side effects of a stem cell/bone marrow transplant. GVHD occurs when the transplanted stem cells recognize the recipient's body as foreign, and "reject" it. Cord blood transplants have had a noticeable lack of GVHD because the stem cells from the donor do not need to match the recipient as with bone marrow.

Do you use chemotherapy or immunosuppressant drugs? No we never use these types of drugs in our treatment process as they are not needed since there are no issues with rejection.

Questions from other Parents that have been answerd by the Doctors in China:

> "The biggest question I have at this point is if the treatment would be available for my son as well, or if this is just a trial or something?" Yes it is available to your son even if he does not meet the parameters of the case study. Given that we already know the treatment is very safe and will do no harm and taking into consideration the amazing early results of the first 3 children that have been treated we have now opened it up to all children in need. We acknowledge that the earlier in life the children are treated the better the results will be and we do not want any child to have to wait to see the aces of thier loved one's.

> "I'm not very comfortable with going overseas, can I get this done in the United States? We do realize that taking your child far across the seas for treatment in a foreign country is incredible and overwhelming for some parents to even ponder. Unfortunately there is no one else any where in the world even attempting to do what we have just accomplished. This is ground breaking, cutting edge treatment that will not likely be available in the US and/or Canada for several years to come. Even if the US began today to attempt to put together a protocol and treatment such as this it would still take 7 to 10 years or more before children could actually receive it even on a limited basis. Children with ONH can not wait 10 years to see. Some children with ONH have do have a visual decline as thier optic nerves continue to atrophy and degrade. For some children this is in fact a "progressive" disorder. Early intervention is a key component in any treatment involving stem cells and nuerons.

> From Julia: What about wiring the brain tissues? How will the kids understand what they see? Known fact > If a baby is born without enough functional eyesight to process the input they do not develop vision. Eyesight is the act of seeing. Vision is the ability to understand what one sees. The stem cells may be able to improve the child’s eyesight but they can not give the child vision. For vision the child must be taught to understand what they see. As part of my protocol I have included a therapy known as Developmental Visual Training. This is based on a therapy approach know as Neurodevelopmental Patterning. It is a type of therapy commonly used with brain inquired children and one I used with my own son. The work aids in teaching the brain to develop pathways around the area of injury such as is the case with a brain injury and/or reactivating dormant portions of the brain and thus creating pathways within a section of the brain that was previously not in use or perhaps in use for another function as is the case with your children. This type of work has been around for well over 20 years and is used worldwide.

> From Julia: Since the stem cells are still an implant could not any implant be rejected? Technically we are not “implanting” the stem cells. We have two delivery methods; one is an “infusion” of the cells, growth factors and cord serum into the blood stream and the other is an “injection” of the cells and growth factors into the spinal canal where they then mix with the SCF (Cerebral Spinal Fluid). * We do not infuse or inject any Red Blood Cells. What creates rejection by the host body is the reaction between the host’s immune system and a foreign substance. When any foreign substance is placed into the body our immune systems are activated by a slight elevation in body temperature. Once activated the body alerts a very specific type of white blood cell (WBC). This type of cell will seek out the newly introduced stem cells. Its job is to determine weather the stem cell is a foreign substance. This determination process is commonly referred to as determining “self” from “other’. The WBC’s will literally bounce around the exterior surface of the stem cell. It is physically checking it for very specific protein markers known as “antigens”. These proteins located on the surface of the cell are like a secrete code and if the WBC does not see the right code it will determine the stem cell to be “self” and thus leave it alone to go about its business. Umbilical Cord Stem Cells lack the antigens that would identify them to the WBC as a foreign cell or as being “other”. The body’s immune system sees them as being “self” and no rejection occurs.

About The Treatment

holliemchugh — Mon, 08 Sep 2008 08:53:57 CDT

The Treatment procedure:
Stem cells are harvested from the umbilical cordblood of full term healthy babies whose mothers have chosen to donate the cords. These are umbilical cords that would otherwise be medical waste, and would be thrown in to the trash. One umbilical cord provides approximatley 300,000 stem cells. Over ten million stem cells are used for each treatment. These treatments are done both by IV and by injection into the spine. The stem cells would rebuild underdevloped areas such as the optic nerves for Izabelle. Another part of the procedure includes different therapies provided by the staff at the hospital for up to 40 days depending on the number of treatments Izabelle recives.

About the treatment:

The procedure, which is not approved in the United Kingdom, involves injecting umbilical cord blood stem cells into the patient's bloodstream and spinal canal, according to information from Beike Biotech, a biotechnology company based in Shenzhen, China. The company supplies stem cells at 11 hospitals in China and one in Thailand for cellular therapy for a variety of diseases. The new cells replace diseased or dysfunctional cells with functional ones, according to the company.

After patients receive stem-cell treatment and return home, it is suggested they receive oxygen treatment for 1 1/2 hours a day, five days a week, for one year to help the stem cells progress, Sallee says.

So far, the four children with optic-nerve diseases who have received stem-cell treatment have reported progress, says Kirshner Ross-Vaden, a registered nurse and Chicago-based vice president of foreign patient relations for Beike Biotech. The first treatment began in June.

"No one in the world has attempted to treat it," said Ross-Vaden, adding that 25 children are scheduled to go to China for treatment within the first six months of next year. "It's really amazing. The fact that no one had any hope for their child and literally almost overnight parents who were told their children would never see, have — for the first time in their lives — a realistic option."

Soon after receiving stem-cell treatments, Barlett, who was blind, was able to see light and recognize faces of her family up close, according to the family's online blog

The Treatment: The treatment approach is a holistic one. We do not only provide patients with stem cell transplants but we also put each patient into a complete custom tailored rehabilitation program. Typically the treatment includes several stem cell transfusions of 10 to 15 million stem cells each over a 20 to 30 day period with rehabilitation approximately 6 days per week (Sundays off). The stem cells are transfused into the patients via the bloodstream (Intravenous Transfusion) and into the Cerebral Spinal Fluid via an Epidural Catheter placed in the lumbar region of the spinal column. With each Stem Cell Transplant we also give the patients a transfusion of Neural Growth Factors to encourage the stem cells to find their targets and transform into new neurons. In addition we also offer our adult clients the opportunity to have a Bone Marrow Transplant during their stay. This involves removing the patients own bone marrow, culturing, expanding and purifying the stem cells from it and then transfusing it back into the patient in two separate transfusions done on different days. This treatment is optional. The rehabilitation program consists of a tailored mix of Physical Therapy, Occupational Therapy, Speech Therapy, Acupuncture, Electronic Muscle Stimulation (EMS), Functional Manipulation, ADL (Activities of Daily Life) education and Chinese massage. Each client receives a full evaluation by the rehabilitation doctors and specialists upon arrival to the hospital and a custom program is worked out just for you. It is this holistic approach combined with the incredible power of the Stem Cells and Neural Growth Factors that gives our clients the best chance for improvements. Not all of these therapies are right for all patients. During your on-site evaluation you and the rehabilitation specialists will determine what the right mix will be.

FAQ;

FAQ; How do the stem cells get to the eye? We do a combination of delivery methods one being via a lumber cath which allows us to inject the cells and growth factors directly into the Cerebral Spinal Fluid where it mixes. This fluid mixture is automatically circulated within the closed system and is pumped up the spinal canal and over the brain thus “bathing” the optic nerves in stem cells and growth factors.

Photo gallery 4

holliemchugh — Sun, 10 Aug 2008 06:01:17 CDT

Mummy and Izabelle	Izabelle in her red chiar	Izabelle waiting for her lunch
Daddy and Izabelle having a pic-nic at the park	Izabelle	Izabelle in her walker

Photo Gallery 3

holliemchugh — Sun, 10 Aug 2008 05:45:49 CDT

Izabelle on boxing day 2007	Izabelle's 1st birthday party 2007.	Izabelle and Daddy.
Izabelle when her hair started to fall out because of her med's.	This is the only part of Izabelle's hair that didnt fall out.	Cute smile's at bath time.
Izabelle's birth.	Mummy And Izzy.	Izabelle and Daddy

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Photo Gallery 2

holliemchugh — Thu, 20 Mar 2008 11:39:39 CDT

Izabelle after her bath.		Izzy in daddy's hat
This is what the tube did to Izzy's face.	Christmas 2007.	Izzy, Mummy and Daddy
Izabelle 2 days old	Izabelle on Halloween 2007	Izzy eating a giant wotsit.

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holliemchugh — Thu, 20 Mar 2008 10:38:04 CDT

Photos of Izabelle!!! xxxx

	Izabelle's first smile!!!
Izzy and Mummy xxx	Izabelle and Daddy, 1st trip to soft play room!!!	Izabelle on her 1st birthday!!!
Izabelle at 5 weeks old.	Izabelle at 6 weeks old.	Izabelle's 1st time in hospital.

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